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KMID : 0359320080480040413
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Korean Journal of Veterinary Research
2008 Volume.48 No. 4 p.413 ~ p.421
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Subacute toxicological study of PG102, a water-soluble extract derived from Actinidia arguta, in SD rats
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Hong Eun-Sil
Kim Mi-Jeong
Kwon Eun-Jung
Kim Li-Hong
Kim Dong-Hyun
Eo Hae-Kwan
Park Eun-Jin
Kim Sun-Young
Kim Seon-Hee
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Abstract
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It was previously found that PG102, a water-soluble extract derived from Actinidia arguta, was able to modulate Th1/Th2 pathways and suppress IgE production resulting in dramatic amelioration of atopic dermatitis in NC/Nga mouse and hairless rat models. In order to evaluate the subacute toxicity of PG102, female and male SD rats were daily fed with various doses of PG102 for 4 weeks. Six week old SD rats were randomly divided into 4 groups and orally administrated with 100-, 300-, and 1,000-mg/kg of PG102 as well as the vehicle only. At the end of the study, no significant differences in the body and organ weights were observed between control and treated rats of both genders. Hematological and blood chemical analysis showed little differences between the animal groups. Neither gross abnormalities nor histopathological changes were found. PG102 produced little or no subacute toxicity and could be used as a safe nutraceutical for the treatment of individuals with allergic diseases including atopic dermatitis.
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KEYWORD
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Actinidia arguta, allergy, complete blood cell counts, PG102, toxicity
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